2型人类免疫缺陷病毒包膜糖蛋白可与人T细胞上的CD8以及CD4分子结合。
Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.
作者信息
Kaneko H, Neoh L P, Takeda N, Akimoto H, Hishikawa T, Hashimoto H, Hirose S, Karaki S, Takiguchi M, Nakauchi H, Kaneko Y, Yamamoto N, Sekigawa I
机构信息
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
J Virol. 1997 Nov;71(11):8918-22. doi: 10.1128/JVI.71.11.8918-8922.1997.
Abstract
We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.
摘要
我们在此报告，人类免疫缺陷病毒2型（HIV-2）包膜糖蛋白（gp105）而非HIV-1 gp120，能够与人T细胞上的CD8分子以及CD4分子结合。这种现象可能导致HIV-1和HIV-2生命周期的差异，并且可能与HIV-1和HIV-2感染的疾病表现差异有关，包括HIV-2感染患者更长的生存期。
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