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Inhibition of lipopolysaccharide and cytokine mixture-mediated hepatocyte nitric oxide synthesis by dimethyl sulfoxide.

作者信息

Liang J F, Akaike T

机构信息

Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.

出版信息

Biochem Biophys Res Commun. 1997 Oct 20;239(2):517-21. doi: 10.1006/bbrc.1997.7506.

DOI:10.1006/bbrc.1997.7506
PMID:9344862
Abstract

Treatment and pretreatment of hepatocytes with 2% dimethyl sulfoxide (DMSO) inhibited lipopolysaccharide and cytokine mixture (LPS/CM)-mediated NO synthesis in hepatocytes without any obvious effects on cell viability. DMSO at concentrations of 0.5-4% stimulated DNA replication and increased albumin secretion in LPS/CM-treated hepatocytes. Genisein, a inhibitor of protein tyrosine kinase (PTK), inhibited LPS/CM-mediated NO synthesis in hepatocytes. These results suggest that PTK is critical for hepatocyte NO synthesis, and DMSO-inhibited NO synthesis may be associated with prevention of LPS/CM-induced PTK activation in hepatocytes.

摘要

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