Loss of heterozygosity or: how I learned to stop worrying and love mitotic recombination.
作者信息
Tischfield J A
机构信息
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202-5251, USA.
出版信息
Am J Hum Genet. 1997 Nov;61(5):995-9. doi: 10.1086/301617.
Abstract
摘要
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本文引用的文献
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"Mistakes happen": somatic mutation and disease.“错误难免”：体细胞突变与疾病
Am J Hum Genet. 1997 Nov;61(5):1000-5. doi: 10.1086/301618.
2
Loss of heterozygosity induced by a chromosomal double-strand break.染色体双链断裂诱导的杂合性缺失
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):8988-93. doi: 10.1073/pnas.94.17.8988.
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The molecular mechanism of aflatoxin B1-induced liver cancer: is mitotic recombination involved?黄曲霉毒素B1诱导肝癌的分子机制：有丝分裂重组参与其中吗？
Mol Carcinog. 1997 Jul;19(3):147-52.
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Loss of heterozygosity analysis in a human fibrosarcoma cell line.
Cytogenet Cell Genet. 1997;76(3-4):214-8. doi: 10.1159/000134552.
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Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.破坏小鼠RAD54会降低电离辐射抗性和同源重组。
Cell. 1997 Apr 18;89(2):195-204. doi: 10.1016/s0092-8674(00)80199-3.
6
Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line.鸡DT40细胞系RAD54基因敲除突变体中X射线抗性和同源重组频率降低。
Cell. 1997 Apr 18;89(2):185-93. doi: 10.1016/s0092-8674(00)80198-1.
7
Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.复杂的染色体机制导致异倍体细胞中APRT杂合性缺失。
Cytogenet Cell Genet. 1996;75(4):216-21. doi: 10.1159/000134486.
8
Isolation and molecular characterization of spontaneous mutants of lymphoblastoid cells with extended loss of heterozygosity.杂合性广泛丢失的淋巴母细胞自发突变体的分离及分子特征分析
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High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.高频体内杂合性缺失主要是有丝分裂重组的结果。
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p53, the cellular gatekeeper for growth and division.p53，细胞生长和分裂的守门人。
Cell. 1997 Feb 7;88(3):323-31. doi: 10.1016/s0092-8674(00)81871-1.
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