Atkinson R A, Appenzeller O
Minerva Med. 1976 Jun 2;67(28):1854-7.
Seventy-two records of patients with systemic lupus erythematosus were reviewed retrospectively. Sixty-one fulfilled the criteria for the disease. Forty-six percent had clinical evidence of central nervous system involvement. The incidence of headache was compared in those with and without central nervous system lupus. No difference in the frequency of headache in the two groups was found and the incidence of hypertension, renal disease and steroid therapy was equally distributed among those with and without headache. A significantly higher incidence of hypertension was found in patients with central nervous system lupus erythematosus. We conclude that headache in systemic lupus erythematosus in the absence of neurologic symptoms or signs is no indication of central nervous system involvement by the process and that small vessel disease of the brain is not a cause of headache.
对72例系统性红斑狼疮患者的记录进行了回顾性研究。其中61例符合该病的诊断标准。46%的患者有中枢神经系统受累的临床证据。比较了有和没有中枢神经系统狼疮的患者中头痛的发生率。两组头痛的频率没有差异，高血压、肾脏疾病和类固醇治疗的发生率在有头痛和没有头痛的患者中分布相同。在中枢神经系统红斑狼疮患者中发现高血压的发生率显著更高。我们得出结论，在没有神经症状或体征的情况下，系统性红斑狼疮中的头痛并不表明该疾病过程累及中枢神经系统，并且脑部小血管疾病不是头痛的原因。
