Speltz M L, Endriga M C, Mouradian W E
Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle 98105, USA.
Cleft Palate Craniofac J. 1997 Sep;34(5):374-9. doi: 10.1597/1545-1569_1997_034_0374_papmap_2.3.co_2.
The current study compared the mental and psychomotor development of infants with nonsyndromic sagittal synostosis (SS) with a demographically matched comparison group without congenital defects. Within the SS group, we tested the hypothesis that age of cranial release would be inversely correlated with mental development.
The design was prospective and longitudinal. Participants were assessed at 4, 12, and 24 months of age.
The study was conducted in a craniofacial clinic at an urban children's hospital.
Participants were 19 infants with SS (consecutive craniofacial program referrals) and 19 demographically matched comparison infants recruited from the community. One infant with SS did not attend the 24-month assessment.
Mental and Psychomotor Indices from the Bayley Scales of Infant Development were the primary outcome measures. Subdomains of development were created using Kohen-Raz scoring procedures. All measures were determined a priori.
Repeated-measures MANOVAs revealed no statistically significant differences in the developmental trajectories of the two groups. None of the SS group infants received Mental Development Index (MDI) scores in the mentally retarded or borderline range of intellectual functioning (i.e., below 78). An inverse correlation (r = -.30) was found between the age at surgery and Bayley growth curve coefficients; however, this association was not statistically significant (p = .10, one-tailed).
Results are consistent with previous studies of the mental and psychomotor development of infants with nonsyndromic craniosynostoses in relation to normative test data. The relation between surgery age and developmental outcome merits further study in a larger sample with a greater range of surgery ages.
本研究比较了患有非综合征性矢状缝早闭（SS）的婴儿与无先天性缺陷、人口统计学特征匹配的对照组婴儿的智力和精神运动发育情况。在SS组中，我们检验了颅骨松解年龄与智力发育呈负相关的假设。
本研究为前瞻性纵向研究。在婴儿4个月、12个月和24个月时对参与者进行评估。
研究在一家城市儿童医院的颅面外科诊所进行。
参与者包括19名患有SS的婴儿（来自颅面项目的连续转诊患者）和19名从社区招募的、人口统计学特征匹配的对照婴儿。一名患有SS的婴儿未参加24个月的评估。
来自贝利婴儿发育量表的智力和精神运动指数是主要观察指标。使用科恩-拉兹评分程序创建发育子领域。所有测量指标均预先确定。
重复测量方差分析显示两组的发育轨迹无统计学显著差异。SS组婴儿的智力发育指数（MDI）得分均未处于智力功能发育迟缓或临界范围（即低于78）。手术年龄与贝利生长曲线系数之间存在负相关（r = -0.30）；然而，这种关联无统计学意义（p = 0.10，单尾）。
结果与先前关于非综合征性颅缝早闭婴儿智力和精神运动发育与标准化测试数据关系的研究一致。手术年龄与发育结局之间的关系值得在手术年龄范围更广的更大样本中进一步研究。
