Milan A R, Markley R L, Fisher R S, Linthicum C M, Witherspoon B, Eidschun A G
Obstet Gynecol. 1976 Jul;48(1):111-6.
Increased attention has been given to cytologic and histopathologic technic in the detection of endometrial lesions because of an increasing incidence of endometrial malignancy. The cervical-vaginal smear as performed by most clinicians is inadequate for the detection of endometrial neoplasia. Existing technics for the detection of endometrial lesions are costly and time consuming. An effective, reliable and economical technic has been developed for rapid smearing and fixation of endometrial cells. The routine endometrial screening of 739 patients (1143 specimens) using the Milan-Markley technic detected 4 cases of endometrial carcinoma, 1 case of carcinoma of the tube, 22 cases of endometrial hyperplasia, and 9 of endometrial polypi. It is hoped that this cytologic method will complement existing histologic detection procedures.
由于子宫内膜恶性肿瘤的发病率不断上升,人们对细胞学和组织病理学技术在子宫内膜病变检测中的关注度日益提高。大多数临床医生所进行的宫颈 - 阴道涂片检查不足以检测出子宫内膜肿瘤。现有的子宫内膜病变检测技术既昂贵又耗时。现已开发出一种有效、可靠且经济的技术,用于快速涂抹和固定子宫内膜细胞。使用米兰 - 马克利技术对739名患者(1143份标本)进行常规子宫内膜筛查,检测出4例子宫内膜癌、1例输卵管癌、22例子宫内膜增生和9例子宫内膜息肉。希望这种细胞学方法能够补充现有的组织学检测程序。