Liang C, Ma T, Cooperwood J S, Du J, Chu C K
Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens 30602, USA.
Carbohydr Res. 1997 Aug 25;303(1):33-8. doi: 10.1016/s0008-6215(97)00143-2.
C-Nucleosides, 4-amino-8-(beta-L-ribofuranosyl)pyrazolo[1, 5-a]-1,3,5-triazine (12) and 4-amino-7-(beta-L-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidine (L-9-deazaadenosine, 22), were synthesized from the key intermediate, 3-dimethylamino-2-(2,3-O-isopropylidene-5-O-trityl-L-ribofuranosyl) acrylonitrile (8), which was prepared from L-xylose in 11 steps.
C-核苷，4-氨基-8-(β-L-呋喃核糖基)吡唑并[1,5-a]-1,3,5-三嗪（12）和4-氨基-7-(β-L-呋喃核糖基)-5H-吡咯并[3,2-d]嘧啶（L-9-脱氮腺苷，22），由关键中间体3-二甲氨基-2-(2,3-O-异亚丙基-5-O-三苯甲基-L-呋喃核糖基)丙烯腈（8）合成，该中间体由L-木糖经11步反应制备而成。
