[Correlation of tetratogenic and antimitotic activity of a number of derivatives of 2,4-diaminopyrimidine].

The effect of 6 substances, analogues of the antimalarial drug chloridine, on the mitotic activity of liver cells in rat embryos and cells of corneal epithelium in adult rats has been studied. A definite correlation was established between the antimitotic activity and the chemical structure of the drugs under study, and namely the length of alkyl radical in the position 6 of pyrimidine ring. The full correlation was noted between the teratogenic and antimitoic activities of these drugs.