Zhou A W, Guo J, Du Y C
Shanghai Institute of Biochemistry, Academia Sinica, China.
Biomed Pept Proteins Nucleic Acids. 1994;1(1):57-8.
Oral administration of the tetrapeptide Asn-Leu-Pro-Arg (NLPR) to memory-impaired rats results in improved acquisition and maintenance of behavioural response and also facilitates nerve growth factor (NGF) expression in the brain. It is suggested that NLPR can ameliorate memory disability by promoting NGF gene expression, so implying that NLPR is a potential drug candidate for curing memory impairment.
给记忆受损的大鼠口服四肽天冬酰胺-亮氨酸-脯氨酸-精氨酸（NLPR）可改善行为反应的获得和维持，并促进大脑中神经生长因子（NGF）的表达。有人认为，NLPR可通过促进NGF基因表达来改善记忆障碍，这意味着NLPR是治疗记忆损伤的潜在候选药物。
