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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Spencer G S, Buyse J, Decuypere E, Rahimi G

Laboratory for Physiology and Immunology of Domestic Animals, Catholic University of Leuven, Heverlee, Belgium.

Br Poult Sci. 1997 Sep;38(4):429-31. doi: 10.1080/00071669708418014.

The role of both insulin-like growth factors (IGF)-I and -II in regulation of growth hormone (GH) secretion in chickens was examined. Seven-week-old male broiler chickens were injected intravenously (i.v.) with recombinant human IGF-I or IGF-II or specific anti-IGF-I or IGF-II immunoglobulins. Blood samples were taken before treatment and at 15 min intervals afterwards for 1 h. Controls received saline i.v. 2. Both IGF-I and IGF-II administration resulted in a rapid, significant decrease in plasma GH concentrations, but the concentrations of both triiodothyronine and thyroxine remained unchanged. 3. Immunisation against both IGF-I and IGF-II produced a significant elevation in plasma GH. 4. These data show that both IGFs can regulate GH concentrations in birds. Furthermore, the immunoneutralisation data suggest that these hormones have a physiological role in the regulation of GH secretion.

研究了胰岛素样生长因子（IGF）-I和-II在调节鸡生长激素（GH）分泌中的作用。给7周龄雄性肉鸡静脉注射重组人IGF-I或IGF-II或特异性抗IGF-I或IGF-II免疫球蛋白。在处理前以及处理后每隔15分钟采集血样，共采集1小时。对照组静脉注射生理盐水。2. 给予IGF-I和IGF-II均导致血浆GH浓度迅速显著降低，但三碘甲状腺原氨酸和甲状腺素的浓度均保持不变。3. 针对IGF-I和IGF-II进行免疫会使血浆GH显著升高。4. 这些数据表明，两种IGF均可调节禽类的GH浓度。此外，免疫中和数据表明这些激素在调节GH分泌中具有生理作用。

Spencer G S, Buyse J, Decuypere E, Rahimi G

Laboratory for Physiology and Immunology of Domestic Animals, Catholic University of Leuven, Heverlee, Belgium.

Br Poult Sci. 1997 Sep;38(4):429-31. doi: 10.1080/00071669708418014.

The role of both insulin-like growth factors (IGF)-I and -II in regulation of growth hormone (GH) secretion in chickens was examined. Seven-week-old male broiler chickens were injected intravenously (i.v.) with recombinant human IGF-I or IGF-II or specific anti-IGF-I or IGF-II immunoglobulins. Blood samples were taken before treatment and at 15 min intervals afterwards for 1 h. Controls received saline i.v. 2. Both IGF-I and IGF-II administration resulted in a rapid, significant decrease in plasma GH concentrations, but the concentrations of both triiodothyronine and thyroxine remained unchanged. 3. Immunisation against both IGF-I and IGF-II produced a significant elevation in plasma GH. 4. These data show that both IGFs can regulate GH concentrations in birds. Furthermore, the immunoneutralisation data suggest that these hormones have a physiological role in the regulation of GH secretion.

研究了胰岛素样生长因子（IGF）-I和-II在调节鸡生长激素（GH）分泌中的作用。给7周龄雄性肉鸡静脉注射重组人IGF-I或IGF-II或特异性抗IGF-I或IGF-II免疫球蛋白。在处理前以及处理后每隔15分钟采集血样，共采集1小时。对照组静脉注射生理盐水。2. 给予IGF-I和IGF-II均导致血浆GH浓度迅速显著降低，但三碘甲状腺原氨酸和甲状腺素的浓度均保持不变。3. 针对IGF-I和IGF-II进行免疫会使血浆GH显著升高。4. 这些数据表明，两种IGF均可调节禽类的GH浓度。此外，免疫中和数据表明这些激素在调节GH分泌中具有生理作用。