慢性和急性乙醇暴露对大鼠肾脏（钠+钾）-ATP酶的影响。
Effects of chronic and acute ethanol exposure on renal (Na + K)-ATPase in the rat.
作者信息
Rodrigo R, Thielemann L
机构信息
Departamento de Medicina Experimental, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
出版信息
Gen Pharmacol. 1997 Nov;29(5):719-23. doi: 10.1016/s0306-3623(97)00009-8.
PMID:9347316
Abstract
- We evaluated the effects of chronic ethanol consumption on the kinetic properties of renal (Na + K)-ATPase and compared them with acute inhibition by ethanol in vitro. 2. When adult rats were fed 20% ethanol for 10 weeks, renal (Na + K)-ATPase activity increased but the sensitivity of the enzyme to ethanol inhibition in vitro was not altered. 3. Vmax was increased by ethanol consumption, whereas K0.5 and nH were not changed. The kinetic parameters of Mg(2+)-ATPase were not affected under the same conditions. 4. We concluded that ethanol-induced tolerance or enhancement of renal (Na + K)-ATPase or both can be explained on the basis of an increase in Vmax.
摘要
- 我们评估了长期摄入乙醇对肾（钠+钾）-ATP酶动力学特性的影响，并将其与乙醇在体外的急性抑制作用进行了比较。2. 当成年大鼠喂食20%乙醇10周时，肾（钠+钾）-ATP酶活性增加，但该酶在体外对乙醇抑制的敏感性未改变。3. 乙醇摄入使Vmax增加，而K0.5和nH未改变。在相同条件下，Mg(2+)-ATP酶的动力学参数未受影响。4. 我们得出结论，乙醇诱导的肾（钠+钾）-ATP酶耐受性或增强作用，或两者兼而有之，可以基于Vmax的增加来解释。
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