Nishijo H, Kita T, Tamura R, Uwano T, Terasawa K, Ono T
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Hippocampus. 1997;7(5):460-4. doi: 10.1002/(SICI)1098-1063(1997)7:5<460::AID-HIPO2>3.0.CO;2-L.
Neuronal activity in the monkey septal nuclei was recorded during performance of a place-dependent go/no-go task in which reward contingencies of the objects were variable with reference to the spatial location of a monkey's cab in one of four places in an experimental room. Of 430 septal neurons recorded, 58 responded differentially to views outside the cab at the four locations of the monkey (place-differential neurons). To investigate the possibility that an ensemble of place-differential neurons represents a space by encoding different scenes (views), responses of the 58 place-differential neurons were analyzed by multidimensional scaling (MDS). The MDS transformed relationships among the four places, expressed as correlation coefficients between all possible pairs of two places based on the 58 place-differential responses, into geometrical relationships in a two-dimensional virtual space. The four places distributed at relative positions in a two-dimensional virtual space derived from the MDS were similar to those in the real experimental room. Furthermore, these correlation coefficients derived from 58 place-differential responses significantly and negatively correlated to behavioral performance in the discrimination of the four places. The results suggest that the ensemble of place-differential responses in the septal nuclei may predict behavioral performance to discriminate places and may represent a space based on the scenes viewed from different locations.
在一项位置依赖的“去/不去”任务执行过程中，对猴子隔核中的神经元活动进行了记录。在该任务中，根据猴子笼子在实验房间四个位置之一的空间位置，物体的奖励条件是可变的。在记录的430个隔核神经元中，有58个对猴子在四个位置时笼子外的视野有不同反应（位置差异神经元）。为了研究一群位置差异神经元是否通过编码不同场景（视野）来表征空间，通过多维标度法（MDS）分析了这58个位置差异神经元的反应。MDS将基于58个位置差异反应的四个位置之间的关系（表示为任意两个位置的所有可能配对之间的相关系数）转换为二维虚拟空间中的几何关系。从MDS得出的二维虚拟空间中四个位置的相对分布与实际实验房间中的分布相似。此外，从58个位置差异反应得出的这些相关系数与辨别四个位置时的行为表现显著负相关。结果表明，隔核中位置差异反应的集合可能预测辨别位置的行为表现，并可能基于从不同位置看到的场景来表征空间。
