硝苯地平/阿替洛尔在胃肠道吸收和生物转化中的相互作用。
Nifedipine/atenolol interactions in gastrointestinal absorption and biotransformation.
作者信息
Iglesias R, Taboada C, Souto C, Martínez-Pacheco R, Gómez-Amoza J L, Concheiro A
机构信息
Departamento de Farmacología, Farmacia y Tecnología, Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
出版信息
Pharmazie. 1997 Sep;52(9):717-20.
The combination of nifedipine and atenolol is widely used for the treatment of hypertension. In the present study, experiments performed in rats indicated that neither drug affects the gastric or intestinal absorption of the other. In assays of the biotransformation of nifedipine in liver homogenates, breakdown was much more rapid in homogenates from male rats than from female rats. In the presence of atenolol, the breakdown rate was significantly increased in homogenates from male rats, and significantly reduced in homogenates from female rats.
硝苯地平和阿替洛尔联合用药广泛用于治疗高血压。在本研究中，对大鼠进行的实验表明，两种药物均不影响另一种药物的胃肠吸收。在肝匀浆中硝苯地平的生物转化试验中，雄性大鼠匀浆中的分解速度比雌性大鼠匀浆中的分解速度快得多。在阿替洛尔存在的情况下，雄性大鼠匀浆中的分解速率显著增加，而雌性大鼠匀浆中的分解速率显著降低。
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