整合素、癌基因与锚定非依赖性 - Suppr

Suppr

超能文献

Integrins, oncogenes, and anchorage independence.

作者信息

Schwartz M A

机构信息

Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

J Cell Biol. 1997 Nov 3;139(3):575-8. doi: 10.1083/jcb.139.3.575.

DOI:10.1083/jcb.139.3.575

PMID:9348275

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2141711/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebb2/2141711/9fd796e27abd/JCB.12474f1.jpg

相似文献

Integrins, oncogenes, and anchorage independence.整合素、癌基因与锚定非依赖性

J Cell Biol. 1997 Nov 3;139(3):575-8. doi: 10.1083/jcb.139.3.575.

Signaling by integrins: implications for tumorigenesis.整合素信号传导：对肿瘤发生的影响

Cancer Res. 1993 Apr 1;53(7):1503-6.

Toward a genetic analysis of cell-matrix adhesion.迈向细胞-基质黏附的遗传分析。

Cold Spring Harb Symp Quant Biol. 1992;57:249-58. doi: 10.1101/sqb.1992.057.01.030.

Extracellular matrix, integrins and focal adhesions.细胞外基质、整合素与黏着斑。

Curr Top Pathol. 1999;93:75-85. doi: 10.1007/978-3-642-58456-5_8.

Adhesion and matrix in vertebrate development.脊椎动物发育中的黏附与基质

Curr Opin Cell Biol. 1994 Oct;6(5):747-51. doi: 10.1016/0955-0674(94)90103-1.

Integrins in development: moving on, responding to, and sticking to the extracellular matrix.发育过程中的整合素：移动、响应并黏附于细胞外基质。

Dev Cell. 2002 Sep;3(3):311-21. doi: 10.1016/s1534-5807(02)00265-4.

Signal transduction from the extracellular matrix.来自细胞外基质的信号转导。

J Cell Biol. 1993 Feb;120(3):577-85. doi: 10.1083/jcb.120.3.577.

Adhesion modulation by antiadhesive molecules of the extracellular matrix.细胞外基质抗黏附分子对黏附的调节作用。

Exp Cell Res. 2000 Nov 25;261(1):104-10. doi: 10.1006/excr.2000.5041.

An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton?一个整合素的“先有鸡还是先有蛋”的问题：细胞外基质和细胞骨架哪个先出现？

Curr Opin Cell Biol. 2000 Oct;12(5):629-33. doi: 10.1016/s0955-0674(00)00142-3.

The role of integrins and extracellular matrix in anchorage-independent growth of a mammary carcinoma cell line.整合素与细胞外基质在一种乳腺癌细胞系非锚定依赖性生长中的作用

Cell Mol Biol (Noisy-le-grand). 1997 May;43(3):455-68.

引用本文的文献

Integrins as Key Mediators of Metastasis.整合素作为转移的关键介质。

Int J Mol Sci. 2025 Jan 22;26(3):904. doi: 10.3390/ijms26030904.

1α,25-dihydroxyvitamin D reduction of MCF10A-ras cell viability in extracellular matrix detached conditions is dependent on regulation of pyruvate carboxylase.1α,25-二羟维生素 D 在细胞外基质脱离条件下降低 MCF10A-ras 细胞活力依赖于调节丙酮酸羧化酶。

J Nutr Biochem. 2022 Nov;109:109116. doi: 10.1016/j.jnutbio.2022.109116. Epub 2022 Aug 4.

Opposite roles of Kindlin orthologs in cell survival and proliferation.Kindlin 同源物在细胞存活和增殖中的相反作用。

Cell Prolif. 2022 Sep;55(9):e13280. doi: 10.1111/cpr.13280. Epub 2022 Jul 20.

ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes.ETV7 通过抑制 IFN 反应基因调节乳腺癌干细胞样细胞特征。

Cell Death Dis. 2021 Jul 27;12(8):742. doi: 10.1038/s41419-021-04005-y.

Tumor-derived exosomes in the regulation of macrophage polarization.肿瘤来源的外泌体在调节巨噬细胞极化中的作用。

Inflamm Res. 2020 May;69(5):435-451. doi: 10.1007/s00011-020-01318-0. Epub 2020 Mar 11.

antibody phage display yields optimal inhibitors of integrin α11/β1.抗体噬菌体展示技术可获得整合素 α11/β1 的最佳抑制剂。

MAbs. 2020 Jan-Dec;12(1):1717265. doi: 10.1080/19420862.2020.1717265.

The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues.果蝇上皮组织中的肿瘤发生初始阶段。

Adv Exp Med Biol. 2019;1167:87-103. doi: 10.1007/978-3-030-23629-8_5.

An Interplay Between Reaction-Diffusion and Cell-Matrix Adhesion Regulates Multiscale Invasion in Early Breast Carcinomatosis.反应扩散与细胞-基质黏附之间的相互作用调节早期乳腺癌转移中的多尺度侵袭。

Front Physiol. 2019 Aug 13;10:790. doi: 10.3389/fphys.2019.00790. eCollection 2019.

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance.整合素信号在癌症中的作用：力学转导、干性、上皮可塑性和治疗抵抗。

Cancer Cell. 2019 Mar 18;35(3):347-367. doi: 10.1016/j.ccell.2019.01.007.

Cell-matrix adhesion controls Golgi organization and function through Arf1 activation in anchorage-dependent cells.细胞-基质黏附通过在锚定依赖性细胞中激活 Arf1 来控制高尔基体的组织和功能。

J Cell Sci. 2018 Aug 17;131(16):jcs215855. doi: 10.1242/jcs.215855.

本文引用的文献

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway.基质黏附与Ras转化均激活磷酸肌醇3-羟基激酶和蛋白激酶B/Akt细胞存活途径。

EMBO J. 1997 May 15;16(10):2783-93. doi: 10.1093/emboj/16.10.2783.

Requirement for Rho in integrin signalling.整合素信号传导中对Rho的需求。

Cell Adhes Commun. 1997 Mar;4(6):387-98. doi: 10.3109/15419069709004456.

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.Cdc42调节不依赖贴壁的生长，并且是Ras转化所必需的。

Mol Cell Biol. 1997 Jun;17(6):3449-58. doi: 10.1128/MCB.17.6.3449.

Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression.整合素连接激酶的过表达促进不依赖贴壁的细胞周期进程。

J Biol Chem. 1997 May 23;272(21):13937-44. doi: 10.1074/jbc.272.21.13937.

Cell anchorage permits efficient signal transduction between ras and its downstream kinases.细胞锚定允许ras与其下游激酶之间进行有效的信号转导。

J Biol Chem. 1997 Apr 4;272(14):8849-52.

Anchorage-dependent cell cycle progression.锚定依赖性细胞周期进程。

J Cell Biol. 1997 Jan 13;136(1):1-4. doi: 10.1083/jcb.136.1.1.

Endogenous GM-CSF is involved as an autocrine growth factor for human osteoblastic cells.内源性粒细胞-巨噬细胞集落刺激因子作为人成骨细胞的自分泌生长因子发挥作用。

J Cell Physiol. 1997 Jan;170(1):35-46. doi: 10.1002/(SICI)1097-4652(199701)170:1<35::AID-JCP5>3.0.CO;2-M.

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport.整合素对c-Abl酪氨酸激酶活性及胞质-核转运的调控

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15174-9. doi: 10.1073/pnas.93.26.15174.

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.整合素可与生长因子协同作用，使受体酪氨酸激酶磷酸化并激活丝裂原活化蛋白激酶：整合素聚集和受体占据的作用。

J Cell Biol. 1996 Dec;135(6 Pt 1):1633-42. doi: 10.1083/jcb.135.6.1633.

Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway.Rho交换因子癌基因介导的转化是由整合素依赖性途径的激活介导的。

EMBO J. 1996 Dec 2;15(23):6525-30.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验