Buechner-Maxwell V, Scott M A, Godber L, Kristensen A
Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, VPI & SU, Blacksburg, VA 24061, USA.
J Vet Intern Med. 1997 Sep-Oct;11(5):304-8. doi: 10.1111/j.1939-1676.1997.tb00470.x.
Neonatal alloimmune thrombocytopenia is recognized as a spontaneous disease of human infants, piglets, and possibly mules, but it has not been previously reported in horses. A 1-day-old Quarter Horse foal presented to Michigan State University Large Animal Clinic with severe thrombocytopenia of unknown origin. Immunoglobulins that bound to the foal's platelets were identified in the mare's plasma, serum, and milk by indirect assays. The immunoglobulins were further shown to recognize platelets from the foal's full brother, born 1 year earlier. These findings, coupled with the clinical course of the foal during its period of hospitalization, strongly suggest that neonatal alloimmune thrombocytopenia can spontaneously occur in neonatal horses. This diagnosis should be considered for foals with severe thrombocytopenia when other causes can be excluded, and platelet antibody assays should be used to support this diagnosis.
新生儿同种免疫性血小板减少症被认为是人类婴儿、仔猪以及可能的骡子的一种自发性疾病，但此前在马匹中尚未有相关报道。一匹1日龄的美国夸特马驹因不明原因的严重血小板减少症被送至密歇根州立大学大型动物诊所。通过间接检测法在母马的血浆、血清和乳汁中鉴定出了与马驹血小板结合的免疫球蛋白。进一步研究表明，这些免疫球蛋白能够识别1年前出生的马驹同父同母的哥哥的血小板。这些发现，再结合马驹住院期间的临床病程，强烈提示新生儿同种免疫性血小板减少症可在新生马中自发发生。当排除其他病因时，对于患有严重血小板减少症的马驹应考虑这一诊断，并且应使用血小板抗体检测来支持这一诊断。
