Mani S
Department of Medicine, University of Chicago, Illinois, USA.
Oncology (Williston Park). 1997 Sep;11(9 Suppl 10):124-7.
UFT (tegafur and uracil) has been studied extensively in Japan, with documented efficacy in hepatobiliary and pancreatic cancer. In the United States, UFT with or without leucovorin has not undergone phase II testing in these malignancies. Our current trial is designed primarily to assess the efficacy in terms of response rates to UFT with leucovorin in patients with advanced hepatobiliary and pancreatic cancer. Secondary objectives include determining response duration, time to disease progression, overall survival, quality of life, and toxicity.
优福定（替加氟尿嘧啶）在日本已得到广泛研究，在肝胆癌和胰腺癌方面有疗效记录。在美国，含或不含亚叶酸的优福定尚未在这些恶性肿瘤中进行II期试验。我们目前的试验主要旨在评估晚期肝胆癌和胰腺癌患者使用含亚叶酸优福定的缓解率方面的疗效。次要目标包括确定缓解持续时间、疾病进展时间、总生存期、生活质量和毒性。
