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惊厥阈值与抗惊厥药物在电惊厥试验中的活性。血清素能系统的作用。

Convulsive thresholds and the activity of anticonvulsants in electroseizure test. The role of serotoninergic system.

作者信息

Przegaliński E

出版信息

Pol J Pharmacol Pharm. 1976;28(2):143-55.

PMID:934946
Abstract

The effect of different compounds modifying the activity of serotoninergic system on the convulsive threshold and on anticonvulsant action of phenyltoin (PHEN) phenobarbital (PHB), m-bromophenyl succinimide (BPHSI) and acetazolamide (ACA) in electroseizure test was studied. The obtained results suggest that 5-HT plays a significant role in the convulsive threshold and in ACA anticonvulsant action. No correlation, however, was observed between anticonvulsant action of the studied drugs and their influence on 5-HT level in brain.

摘要

研究了不同化合物对血清素能系统活性的调节作用，以及在电惊厥试验中这些化合物对苯妥英（PHEN）、苯巴比妥（PHB）、间溴苯基琥珀酰亚胺（BPHSI）和乙酰唑胺（ACA）惊厥阈值及抗惊厥作用的影响。所得结果表明，5-羟色胺在惊厥阈值及ACA的抗惊厥作用中起重要作用。然而，在所研究药物的抗惊厥作用与其对脑内5-羟色胺水平的影响之间未观察到相关性。

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Pol J Pharmacol Pharm. 1976;28(2):143-55.
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引用本文的文献

1
Serotonergic mechanism in seizures kindled from the rabbit amygdala.源自兔杏仁核点燃癫痫发作中的5-羟色胺能机制。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):56-8. doi: 10.1007/BF00507228.
2
Evidence against serotonin involvement in the tonic component of electrically induced convulsions and in carbamazepine anticonvulsant activity.有证据表明血清素不参与电诱导惊厥的强直成分及卡马西平的抗惊厥活性。
Psychopharmacology (Berl). 1979;66(1):79-85. doi: 10.1007/BF00431994.