Concordet D, Toutain P L
Ecole Nationale Vétérinaire de Toulouse-INRA, Unité Associée INRA de Physiopathologie et Toxicologie Expérimentales, France.
J Vet Pharmacol Ther. 1997 Oct;20(5):374-9. doi: 10.1046/j.1365-2885.1997.00077.x.
The study of a veterinary drug for use in a food producing animal requires the estimation of the withdrawal time which is defined as the time when it can be assessed with a controlled risk that a given percentage (less than 100(1-alpha)%) of animals have a concentration below the Maximal Limit of Residue (MRL). A simple and understandable non-parametric method which allows the control of the risk is presented. This method does not require the assumptions needed for the correct use of the current method of estimation to be met. A simple example which illustrates the use of this method is presented.
对用于食用动物的兽药进行研究时，需要估算休药期，休药期定义为在可控风险下，能够评估特定百分比（小于100(1-α)%）的动物体内药物浓度低于最大残留限量（MRL）的时间。本文提出了一种简单易懂的非参数方法，该方法可控制风险。此方法无需满足正确使用当前估算方法所需的假设条件。文中给出了一个说明该方法用法的简单示例。
