Myshliakova N V, Auna Z P, Indulen Iu I, Klusha V E, Chipens G I
Probl Endokrinol (Mosk). 1976 May-Jun;22(3):85-9.
The authors studied comparatively the properties of two angiotensin II analogues, a new compound (1-hydantoin acid, 5-valine, 8-alanine)-angiotensin II (compound III) and (1-asparagine, 5-valine, 8-alanine)-angiotensin II (compound II), as of the myotropic action of angiotensinamide (these experiments were conducted on the rat isolated ascending colon); pressor action of the hormone was investigated in experiments on anesthetized rats. A competitive character of the antagonism--within the range of low concentrations of the analogues--10(-10)--10(-9) M/l--was revealed in vitro. No antagonism was expressed against the nonspecific myotropic agents--acetylcholine and bradykinin. In vivo compounds II and II manifested the antagonistic action against angiotensinamide beginning from the doses of 100 and 50 gamma/kg, respectively.
作者比较研究了两种血管紧张素II类似物的性质，一种新化合物（1-乙内酰脲酸，5-缬氨酸，8-丙氨酸）-血管紧张素II（化合物III）和（1-天冬酰胺，5-缬氨酸，8-丙氨酸）-血管紧张素II（化合物II），就血管紧张素酰胺的肌动作用而言（这些实验是在大鼠离体升结肠上进行的）；在麻醉大鼠实验中研究了该激素的升压作用。在体外揭示了拮抗剂的竞争性特征——在低浓度类似物范围内——10（-10）——10（-9）M/升。对非特异性肌动剂——乙酰胆碱和缓激肽没有拮抗作用。在体内，化合物II和III分别从100和50微克/千克的剂量开始表现出对血管紧张素酰胺的拮抗作用。
