Relationship of glomerular filtration rate and hypoalbuminaemia to renal glucose reabsorption.

Ten glucose titration studies were performed on 10 patients with chronic renal disease without renal failure. Six of them had nephrotic syndrome. The results show that patients with marked hypoalbuminaemia (i.e. patients with nephrotic syndrome) have a marked splay in the glucose titration curve. This observation is consistent with the hypothesis that physical factors play a main role in tubular reabsorption and indicate that proximal tubular reabsorption is decreased in nephrotic syndrome.