Soutto M, Molinero P, Guerrero J M
Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Sevilla, Spain.
Cell Mol Life Sci. 1997 Aug;53(8):697-9. doi: 10.1007/s000180050090.
In the present study we show that thymus type II thyroxine deiodinase activity exhibits a nyctohemeral profile, with basal values during the day and high values at night. This rhythmic character is dependent on neuroadrenergic input since exposure to continuous light at night completely abolished the nocturnal rise of the enzyme activity. However, treatment with isoproterenol under light exposure at night restored it.
在本研究中,我们发现胸腺Ⅱ型甲状腺素脱碘酶活性呈现昼夜节律,白天酶活性处于基础水平,夜间则升高。这种节律特性依赖于神经肾上腺素能输入,因为夜间持续光照会完全消除该酶活性的夜间升高。然而,夜间光照下用异丙肾上腺素治疗可使其恢复。