水仙生物碱前多花水仙碱对劳氏白血病的治疗活性：与多花水仙碱和链黑菌素的比较。

Therapeutic activity of pretazettine, a narcissus alkaloid on Rauscher leukemia: comparison with tazettine and streptonigrin.

作者信息

Furusawa E, Furusawa S, Lee J Y, Patanavanich S

出版信息

Proc Soc Exp Biol Med. 1976 Jun;152(2):186-91. doi: 10.3181/00379727-152-39357.

Abstract

The therapeutic activity of narcissus alkaloid pretazettine HC1 (PTZ) on established Rauscher leukemia has been demonstrated and compared with the isomer tazettine (TZ) and an antibiotic, streptonigrin (SN). PTZ and SN showed remarkable prolongation effect on the life span of the leukemic mice and the antiviral activity has been confirmed in mouse 3T3 cells infected with Rauscher virus. TZ showed no significant activity in the leukemic mice and was inhibitory to the virus growth in the cells at much higher doses than PTZ. It is suggested that the stereochemical rearrangement from PTZ to TZ inactivates the biological activity of PTZ.

摘要

水仙生物碱盐酸前多花水仙碱（PTZ）对已形成的劳舍尔白血病的治疗活性已得到证实，并与异构体多花水仙碱（TZ）和一种抗生素链黑菌素（SN）进行了比较。PTZ和SN对白血病小鼠的寿命显示出显著的延长作用，并且在感染劳舍尔病毒的小鼠3T3细胞中已证实其具有抗病毒活性。TZ在白血病小鼠中未显示出显著活性，并且在比PTZ高得多的剂量下对细胞中的病毒生长具有抑制作用。有人认为，从PTZ到TZ的立体化学重排使PTZ的生物活性失活。