Bahr J, Shahabi N, Waldron E, Nalbandov A V
Proc Soc Exp Biol Med. 1976 Jun;152(2):210-2. doi: 10.3181/00379727-152-39362.
The ovarian steroids, estrogen, androgen, and progestin, were measured in the peripheral plasma of adult female rabbits that were either conscious or anesthetized with sodium pentobarbital (nembutal) or halothane. Concentrations of estrogen, androgens, and progestin were determined before and at 10 and 45 min after systemic injection of either buffer or LH. In the controls androgen levels were significantly different between animals anesthetized with nembutal and halothane. However, the greatest treatment effect was noted in plasma progestin concentrations which were significantly elevated in halothane-anesthetized animals in comparison to the conscious and nembutal-anesthetized animals. Following LH, the androgen and progestin levels were significantly elevated over basal levels. Most likely the treatment effect observed in the controls was still present but was overridden by the increased release of steroids following gonadotrophin stimulation. This study suggests that halothane, in contrast to nembutal, does significantly elevate peripheral progestin and androgen levels.
在成年雌性家兔的外周血浆中测量了卵巢甾体激素，即雌激素、雄激素和孕激素，这些家兔分别处于清醒状态，或用戊巴比妥钠（戊巴比妥）或氟烷麻醉。在全身注射缓冲液或促黄体生成素（LH）之前以及注射后10分钟和45分钟时，测定雌激素、雄激素和孕激素的浓度。在对照组中，用戊巴比妥和氟烷麻醉的动物之间雄激素水平存在显著差异。然而，观察到的最大治疗效果体现在血浆孕激素浓度上，与清醒和用戊巴比妥麻醉的动物相比，氟烷麻醉的动物血浆孕激素浓度显著升高。注射LH后，雄激素和孕激素水平显著高于基础水平。很可能在对照组中观察到的治疗效果仍然存在，但被促性腺激素刺激后甾体激素释放增加所掩盖。这项研究表明，与戊巴比妥不同，氟烷确实会显著提高外周孕激素和雄激素水平。
