Parisi V, Pernini C, Guinetti C, Neuschuler R, Bucci M G
Eye Clinic, University of Roma Tor Vergata, Italy.
Eur J Ophthalmol. 1997 Jul-Sep;7(3):229-35. doi: 10.1177/112067219700700305.
To assess nerve conduction in visual pathways in patients with open-angle glaucoma.
Pattern-electroretinograms (PERG) and visual-evoked potentials (VEP) were simultaneously recorded in 16 patients with open-angle glaucoma (POAG) and 15 age-matched controls. The visual stimuli were checker-board patterns (the check edges subtend 15'; the contrast was 70% and reversed at the rate of 2 reversals/s).
POAG patients showed significantly higher PERG and VEP latencies (ANOVA: P < 0.01) and significantly lower amplitudes than controls; the retinocortical time (RCT: difference between VEP P100 latency and PERG P50 latency) was longer (P < 0.01) in POAG than controls and the longer RCT was correlated with the reduced PERG amplitude (r:0.798, P < 0.01).
This suggests that POAG patients have an involvement of the innermost retinal layers and impaired nerve conduction in their visual pathways.
评估开角型青光眼患者视觉通路中的神经传导。
对16例开角型青光眼（POAG）患者和15例年龄匹配的对照者同时记录图形视网膜电图（PERG）和视觉诱发电位（VEP）。视觉刺激为棋盘格图案（方格边缘视角为15'；对比度为70%，以每秒2次反转的速率反转）。
POAG患者的PERG和VEP潜伏期显著更长（方差分析：P < 0.01），且振幅显著低于对照者；POAG患者的视网膜皮质时间（RCT：VEP P100潜伏期与PERG P50潜伏期之差）比对照者更长（P < 0.01），且更长的RCT与降低的PERG振幅相关（r：0.798，P < 0.01）。
这表明POAG患者最内层视网膜层受累，其视觉通路中的神经传导受损。
