Uçakhan O, Salih M, Altan S, Ozdemir O
Department of Ophthalmology, Faculty of Medicine, University of Ankara, Turkey.
Eur J Ophthalmol. 1997 Jul-Sep;7(3):256-61. doi: 10.1177/112067219700700310.
The purpose of this study was to evaluate the hemodynamic changes occurring in the ophthalmic vasculature of eyes with Behçet's disease in a controlled clinical trial. Both eyes of patients with retinal involvement due to Behçet's disease were consecutively evaluated and were established as having mild or severe retinal vasculitis according to the ophthalmoscopic and fundus fluorescein angiographic findings. One eye from each patient was randomly selected and 25 eyes with mild to moderate and 25 eyes with severe vasculitis were identified. Color Doppler imaging (CDI) was used to quantitate blood flow velocities and vascular resistance in the ophthalmic artery (OA), central retinal artery (CRA) and central retinal vein (CRV) of these patients and those of 25 healthy volunteers. All three groups were age- and sex-matched. In the OA, peak systolic, end diastolic and average flow velocities were significantly higher in patients with Behçet's disease than in the control group (p < 0.05). CRA blood flow velocities of patients with severe retinal involvement were significantly lower than those with mild to moderate vasculitis and control groups and the average vascular resistance was significantly higher than in the control group (p < 0.05). Additionally, the average blood flow velocities in the CRV of patients with severe vasculitis were significantly lower than in mild to moderate vasculitis and control patients. Marked circulatory changes were seen in the ophthalmic vasculature of eyes with Behçet's disease. Although larger studies are required to define the true sensitivity and specificity of this technique, these initial results suggest that CDI could play a major part in the assessment of patients with ocular Behçet's disease.
本研究的目的是在一项对照临床试验中评估白塞病患者眼部血管系统发生的血流动力学变化。对白塞病所致视网膜受累患者的双眼进行连续评估，并根据检眼镜和眼底荧光血管造影结果确定为轻度或重度视网膜血管炎。从每位患者中随机选择一只眼睛，确定25只轻度至中度血管炎的眼睛和25只重度血管炎的眼睛。使用彩色多普勒成像（CDI）对这些患者以及25名健康志愿者的眼动脉（OA）、视网膜中央动脉（CRA）和视网膜中央静脉（CRV）中的血流速度和血管阻力进行定量分析。所有三组在年龄和性别上相匹配。在眼动脉中，白塞病患者的收缩期峰值、舒张末期和平均血流速度显著高于对照组（p<0.05）。重度视网膜受累患者的视网膜中央动脉血流速度显著低于轻度至中度血管炎患者和对照组，且平均血管阻力显著高于对照组（p<0.05）。此外，重度血管炎患者视网膜中央静脉的平均血流速度显著低于轻度至中度血管炎患者和对照患者。在白塞病患者的眼部血管系统中观察到明显的循环变化。尽管需要更大规模的研究来确定该技术的真正敏感性和特异性，但这些初步结果表明，彩色多普勒成像可能在眼部白塞病患者的评估中发挥重要作用。
