Anteby I, Kramer M, Rahav G, Benezra D
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Eur J Ophthalmol. 1997 Jul-Sep;7(3):294-6. doi: 10.1177/112067219700700316.
Endogenous endophthalmitis due to Aspergillus is rare affecting the severely immunosuppressed population, in particular recipients of heart and lung transplants. Ocular involvement of aspergillosis has always been observed late in the course of the disease.
A young woman noted blurred vision in one eye three weeks after lung transplantation. At this stage, no systemic manifestations of fungal infection were detected and the ocular findings were attributed to viral infection.
Twenty-four hours after the original ocular complaint, an aggressive endophthalmitis developed in the left eye. The possibility of fungal endophthalmitis was raised. Within 48 hours of her first ocular complaint the patient died. Cultures from a vitreous tap and from autopsy ocular specimens were positive for Aspergillus fumigatus.
Aspergillus endopthalmitis may occur in patients undergoing lung transplantation despite antifungal therapy. Increased awareness of this unusual entity may be life and vision saving in these patients.
由曲霉菌引起的内源性眼内炎罕见，多见于严重免疫抑制人群，尤其是心肺移植受者。曲霉病的眼部受累通常在疾病晚期才被观察到。
一名年轻女性在肺移植三周后出现单眼视力模糊。此时，未检测到真菌感染的全身表现，眼部症状被归因于病毒感染。
在最初眼部不适24小时后，左眼发生了侵袭性眼内炎。真菌性眼内炎的可能性被提出。在首次眼部不适48小时内，患者死亡。玻璃体穿刺培养物和尸检眼部标本培养结果显示烟曲霉菌阳性。
尽管进行了抗真菌治疗，但肺移植患者仍可能发生曲霉菌性眼内炎。提高对这种罕见疾病的认识可能会挽救这些患者的生命和视力。
