主要组织相容性复合体II类基因影响丙型肝炎病毒感染的结果。

Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection.

作者信息

Alric L, Fort M, Izopet J, Vinel J P, Charlet J P, Selves J, Puel J, Pascal J P, Duffaut M, Abbal M

机构信息

Service de Médecine Interne, Hôpital Purpan, INSERM Unité CJF-9107, Toulouse, France.

出版信息

Gastroenterology. 1997 Nov;113(5):1675-81. doi: 10.1053/gast.1997.v113.pm9352872.

DOI:10.1053/gast.1997.v113.pm9352872

PMID:9352872

Abstract

BACKGROUND & AIMS: The host's immune response may influence the course of hepatitis C virus (HCV) infection. The aim of this study was to investigate the distribution of HLA class II alleles in white subjects who spontaneously recovered from HCV infection compared with that in patients with persistent infection.

METHODS

HLA-DRB1 and -DQB1 typing were performed in 103 consecutive patients with persistent HCV infection (HCV antibody positive, HCV RNA positive) and in 25 subjects with transient HCV infection (HCV antibody positive, persistently negative HCV RNA).

RESULTS

No significant differences between subjects with transient or persistent infection were observed for age, sex, source of infection, or HCV serotype. The frequency of DQB10301 and DRB11101 alleles was higher in patients with transient infection than in those with persistent infection (84% vs. 30.8%, 40% vs. 9.8%; P < 0.01 and P < 0.02, respectively [Bonferroni correction]). DRB1 and DQB1 alleles did not influence viral load as an independent factor. Mean Knodell's scores were lower in patients with DQB10301 allele (6.12 +/- 0.4) than in those negative for DQB10301 (7.37 +/- 0.3; P < 0.05).

CONCLUSIONS

Our results suggest that host- rather than virus-related factors are probably involved in the spontaneous clearance of HCV.

摘要

背景与目的

宿主的免疫反应可能会影响丙型肝炎病毒（HCV）感染的病程。本研究旨在调查自发清除HCV感染的白人受试者与持续感染患者中HLA II类等位基因的分布情况。

方法

对103例连续的HCV持续感染患者（HCV抗体阳性，HCV RNA阳性）和25例HCV短暂感染受试者（HCV抗体阳性，HCV RNA持续阴性）进行HLA - DRB1和 - DQB1分型。

结果

短暂感染和持续感染的受试者在年龄、性别、感染源或HCV血清型方面未观察到显著差异。短暂感染患者中DQB10301和DRB11101等位基因的频率高于持续感染患者（分别为84%对30.8%，40%对9.8%；P < 0.01和P < 0.02[Bonferroni校正]）。DRB1和DQB1等位基因作为独立因素不影响病毒载量。携带DQB10301等位基因的患者平均Knodell评分（6.12±0.4）低于DQB10301阴性患者（7.37±0.3；P < 0.05）。