免疫的塞内加尔成年人中恶性疟原虫和裂殖子表面蛋白1特异性抗体的亚型平衡
Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults.
作者信息
Nguer C M, Diallo T O, Diouf A, Tall A, Dieye A, Perraut R, Garraud O
机构信息
Laboratoire d'Immunologie, Institut Pasteur, Dakar, Sénégal.
出版信息
Infect Immun. 1997 Nov;65(11):4873-6. doi: 10.1128/iai.65.11.4873-4876.1997.
Abstract
This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.
摘要
这项研究表明，在临床免疫的塞内加尔成年人中，根据研究地点的不同，针对恶性疟原虫无性血液阶段和裂殖子表面蛋白1的抗体，其同种型分布存在显著差异。与季节性传播地区相比，在常年传播地区，免疫球蛋白M（IgM）与IgG之间以及IgG3与IgG1抗体之间的关系有所不同。这表明抗体类别和/或亚类的产生及利用在针对此类抗原的保护性免疫调节中发挥着作用。
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