Latremouille C, Genevaz D, Hu M C, Schussler O, Goussef N, Mandet C, Bruneval P, Haeffner-Cavaillon N, Carpentier A, Glotz D
INSERM U 430, Hôpital Broussais, Paris, France.
Clin Exp Immunol. 1997 Oct;110(1):122-6. doi: 10.1046/j.1365-2249.1997.4591358.x.
Xenotransplantation between discordant species leads to a hyperacute rejection mediated by natural antibodies, both of the IgG and IgM isotypes, activation of complement and endothelial cell activation. The combination of these mechanisms leads to a transplant survival of minutes to a few hours. Polyclonal human immunoglobulins for intravenous use (IVIg) from normal donors have proved effective in a number of antibody-mediated disorders, as well as in inflammatory disorders. We demonstrate that administration of IVIg in a guinea pig to rat model of cardiac xenografting can effectively delay hyperacute rejection. This effect is mediated by the F(ab')2 fragments of IVIg, and is correlated to an anti-complementary activity.
不同物种间的异种移植会引发由天然抗体介导的超急性排斥反应，这些天然抗体包括IgG和IgM两种同种型，会激活补体并导致内皮细胞活化。这些机制共同作用，导致移植器官在几分钟到几小时内就会失去存活能力。来自正常供体的静脉注射用人多克隆免疫球蛋白（IVIg）已被证明在多种抗体介导的疾病以及炎症性疾病中有效。我们证明，在豚鼠到大鼠的心脏异种移植模型中给予IVIg可有效延迟超急性排斥反应。这种效应是由IVIg的F(ab')2片段介导的，并且与抗补体活性相关。
