肿瘤内高水平的细胞因子介导大鼠组织细胞瘤有效消退。
High intratumoural level of cytokines mediates efficient regression of a rat histiocytoma.
作者信息
Khar A, Muralikrishna K, Varalakshmi C
机构信息
Centre for Cellular & Molecular Biology, Hyderabad, India.
出版信息
Clin Exp Immunol. 1997 Oct;110(1):127-31. doi: 10.1046/j.1365-2249.1997.5021401.x.
We have studied the role of cytokines in the spontaneous regression of AK-5 histiocytoma in syngeneic rats. Animals in which the tumour regresses show high levels of cytokines in the serum compared with animals which succumb to the tumour, and levels of IL-2, IL-4, IL-12, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are significantly higher in tumour tissue of the former. Thus there is an association between rejection of the tumour and the levels of cytokines present in the tumour mass. Our results also suggest a predominant Th1-type of response in those rats that display early tumour rejection.
我们研究了细胞因子在同基因大鼠中 AK-5 组织细胞瘤自发消退过程中的作用。与肿瘤致死的动物相比，肿瘤消退的动物血清中细胞因子水平较高，且前者肿瘤组织中白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-12（IL-12）、干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）的水平显著更高。因此，肿瘤的排斥与肿瘤块中存在的细胞因子水平之间存在关联。我们的结果还表明，在那些表现出早期肿瘤排斥的大鼠中存在主要的 Th1 型反应。
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