七叶树（欧洲七叶树种子）中的七叶皂苷Ia、Ib、IIa和IIb对动物急性炎症的影响。
Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals.
作者信息
Matsuda H, Li Y, Murakami T, Ninomiya K, Yamahara J, Yoshikawa M
机构信息
Kyoto Pharmaceutical University, Japan.
出版信息
Biol Pharm Bull. 1997 Oct;20(10):1092-5. doi: 10.1248/bpb.20.1092.
We investigated the effects of escins Ia, Ib, and IIb isolated from horse chestnut, the seeds of Aesculus hippocastanum L., and desacylescins I and II obtained by alkaline hydrolysis of escins on acute inflammation in animals (p.o.). Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibited the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibited that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibited the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibited the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Desacylescins I and II (200 mg/kg) showed no effect. With regard to the relationship between their chemical structures and activities, the acyl groups in escins were essential. Escins Ib, IIa, and IIb with either the 21-angeloyl group or the 2'-O-xylopyranosyl moiety showed more potent activities than escin Ia which had both the 21-tigloyl group and the 2'-O-glucopyranosyl moiety.
我们研究了从欧洲七叶树（Aesculus hippocastanum L.）种子中分离得到的七叶皂苷Ia、Ib和IIb以及通过七叶皂苷碱水解得到的去酰基七叶皂苷I和II对动物急性炎症（口服给药）的影响。七叶皂苷Ia、Ib、IIa和IIb（50 - 200 mg/kg）可抑制小鼠醋酸和大鼠组胺诱导的血管通透性增加。七叶皂苷Ib、IIa和IIb（50 - 200 mg/kg）也可抑制大鼠血清素诱导的血管通透性增加，但七叶皂苷Ia无此作用。七叶皂苷Ia、Ib、IIa和IIb（200 mg/kg）可抑制大鼠角叉菜胶诱导的后爪水肿第一阶段。七叶皂苷Ia（200 mg/kg）以及七叶皂苷Ib、IIa和IIb（50 - 200 mg/kg）可抑制小鼠48/80诱导的搔抓行为，但七叶皂苷Ia作用最弱。去酰基七叶皂苷I和II（200 mg/kg）无作用。关于它们的化学结构与活性之间的关系，七叶皂苷中的酰基至关重要。具有21 - 当归酰基或2'-O - 吡喃木糖基部分的七叶皂苷Ib、IIa和IIb比同时具有21 - 惕各酰基和2'-O - 吡喃葡萄糖基部分的七叶皂苷Ia活性更强。
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