Yoshikawa M, Harada E, Murakami T, Matsuda H, Wariishi N, Yamahara J, Murakami N, Kitagawa I
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1357-9. doi: 10.1248/cpb.42.1357.
Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassays, while desacylescins-I and II had no activity.
从欧洲七叶树种子中分离出了五种三萜寡糖苷，分别命名为爱斯cin-Ia、Ib、IIa、IIb和IIIa，并根据化学和物理化学证据确定了它们的化学结构。发现爱斯cin-Ia、Ib、IIa和IIb对大鼠乙醇吸收有抑制作用，对口服葡萄糖耐量试验有降血糖活性。其中，爱斯cin-IIa和IIb在两种生物测定中均表现出较高活性，而去酰基爱斯cin-I和II则无活性。
