Alpert J S, Beller G A, Giamber S R, Saltz S B
Prostaglandins. 1976 May;11(5):783-97. doi: 10.1016/0090-6980(76)90187-8.
The effect of prostaglandin E1 (PGE1) on central and peripheral hemodynamics was studied in seven conscious dogs under conditions of normoxia and hypobaric hypoxia to ascertain if hypoxia attenuated the cardiovascular actions of PGE1. Silastic catheters were chronically implanted in the pulmonary artery, left atrium, and aorta. Acute hypoxia was produced in a hypobaric chamber maintained at 446 mmHg pressure (14,000 feet). PGE1 at sea level (normoxia) resulted in significant increases in heart rate, cardiac output, left ventricular stroke work and pulmonary blood volume as well as significant decreases in aortic, pulmonary arterial, and left atrial pressures. During hypobaric hypoxia, PGE1 produced essentially identical effects on all hemodynamic parameters except pulmonary blood volume and pulmonary arterial pressure where marked attenuation of PGE1 action occurred.
在常氧和低压缺氧条件下，对7只清醒犬研究了前列腺素E1（PGE1）对中心和外周血流动力学的影响，以确定缺氧是否会减弱PGE1的心血管作用。将硅橡胶导管长期植入肺动脉、左心房和主动脉。在压力维持在446 mmHg（14,000英尺）的低压舱中产生急性缺氧。在海平面（常氧）时，PGE1可导致心率、心输出量、左心室搏功和肺血容量显著增加，同时主动脉、肺动脉和左心房压力显著降低。在低压缺氧期间，PGE1对所有血流动力学参数产生基本相同的影响，但肺血容量和肺动脉压力除外，在这些参数上PGE1的作用明显减弱。
