Brandalise S R, Suguihara C Y, Succi R M, Muller R L, Toledo R J
Rev Bras Pesqui Med Biol. 1976 Jan-Feb;9(1):37-44.
Blood coagulation tests were performed in 93 newborn infants with different Apgar score at the 1st and 5th minutes of life. The laboratorial determinations were periodically performed at 0, 24 and 48 hours of life. The following tests were performed: bleeding time, whole blood clotting time, prothrombin time, kaolin-cephalin clotting time, thrombin time, dosage of factors I, V, VIII and X, clot retraction, platelet count, englobulin lysis time and the tourniquet test. Immediately after birth, the mean values of the blood coagulation factors were significantly different among the groups, with the exception of the whole blood clotting time and the platelet count. Those differences were due to the presence of the more depressed neonates. Although these results could indicate some degree of hepatic damage, it was apparent that an activation of the blood coagulation mechanisms took place, leading to a consumption coagulopathy. The infants who died (10) presented clinical and laboratorial data suggestive of disseminated intravascular coagulation (DIC). Necroscopic findings of microthrombosis in the liver and in the central nervous system were diagnosed in two infants.
对93名出生后第1分钟和第5分钟阿氏评分不同的新生儿进行了凝血测试。在出生后0、24和48小时定期进行实验室检测。检测项目如下：出血时间、全血凝固时间、凝血酶原时间、白陶土部分凝血活酶时间、凝血酶时间、因子I、V、VIII和X的定量、血块退缩、血小板计数、球蛋白溶解时间和束臂试验。出生后立即发现，除全血凝固时间和血小板计数外，各组凝血因子的平均值存在显著差异。这些差异是由于存在病情较重的新生儿。尽管这些结果可能表明存在一定程度的肝损伤，但显然发生了凝血机制的激活，导致消耗性凝血病。死亡的10名婴儿的临床和实验室数据提示存在弥散性血管内凝血（DIC）。两名婴儿的肝脏和中枢神经系统出现了显微镜下血栓形成的尸检结果。
