Kutílek S, Bayer M, Stĕpán J J
Department of Pediatrics, 1st Medical Faculty, Charles University, Prague, Czech Republic.
Acta Univ Carol Med (Praha). 1994;40(1-4):47-51.
Transient hyperphosphatasaemia (TH) is a benign disorder characterized by transient elevation of S-ALP activity not exceeding duration of 4 months in children under 5 years of age, with elevated activity of bone isoenzymes of ALP with no signs of bone or liver disease and variable unrelated symptoms. We observed 19 children with TH and in 3 patients with markedly elevated S-ALP activity we found increased excretion of urinary hydroxyproline, suggesting increased bone resorption followed by bone formation. In 3 children with history of TH, bone mineral density (BMD) was measured and found to be normal. Transient increased bone resorption followed by bone formation during the course of TH can not be ruled out, but this has no negative impact on BMD.
短暂性高磷酸酶血症（TH）是一种良性病症，其特征为5岁以下儿童血清碱性磷酸酶（S-ALP）活性短暂升高，持续时间不超过4个月，碱性磷酸酶骨同工酶活性升高，无骨骼或肝脏疾病迹象，且伴有各种不相关症状。我们观察了19例TH患儿，在3例S-ALP活性显著升高的患者中，我们发现尿羟脯氨酸排泄增加，提示骨吸收增加随后伴有骨形成。在3例有TH病史的儿童中，测量了骨密度（BMD），发现其正常。TH病程中不能排除短暂性骨吸收增加随后伴有骨形成的情况，但这对骨密度没有负面影响。
