Bhagwat V R
Govt. Medical College, Miraj.
Indian J Med Sci. 1997 Feb;51(2):45-51.
Serum Lipid peroxides (LP) were measured as an index of free radical mediated lipid peroxidation in sixty normal healthy individuals. Erythrocyte superoxide dismutase (SOD) activity was also measured simultaneously in the subjects. The serum LP levels were found to be increased progressively with age, while erythrocyte SOD was, in contrast, found to be decreased with age. There was excellent positive correlation between serum LP and age (r = 0.959) while the erythrocyte SOD was inversely correlated with age (r = -0.845). The serum LP and erythrocyte SOD have also shown some inverse relationship (r = -0.8395). The result indicate that the balance between antioxidant & pro-oxidant factors in free radical metabolism shifts towards increased lipid peroxidation with advancing age.
在60名正常健康个体中测量血清脂质过氧化物（LP），作为自由基介导的脂质过氧化指标。同时也在这些受试者中测量红细胞超氧化物歧化酶（SOD）活性。发现血清LP水平随年龄增长而逐渐升高，而红细胞SOD则相反，随年龄增长而降低。血清LP与年龄之间存在极好的正相关（r = 0.959），而红细胞SOD与年龄呈负相关（r = -0.845）。血清LP与红细胞SOD之间也呈现出一定的负相关关系（r = -0.8395）。结果表明，随着年龄增长，自由基代谢中抗氧化剂和促氧化剂因素之间的平衡向脂质过氧化增加的方向转变。
