小鼠心脏移植中新生内膜形成的形态计量分析：III. 间质纤维化与新生内膜形成的分离。
Morphometric analysis of neointimal formation in murine cardiac grafts: III. Dissociation of intestitial fibrosis from neointimal formation.
作者信息
Armstrong A T, Strauch A R, Starling R C, Sedmak D D, Orosz C G
机构信息
Department of Internal Medicine, The Ohio State University College of Medicine, Columbus 43210, USA.
出版信息
Transplantation. 1997 Oct 27;64(8):1198-202. doi: 10.1097/00007890-199710270-00020.
BACKGROUND
This study examined the relationship between transplant vascular sclerosis (TVS) and tissue fibrosis, features of chronic rejection that can develop rapidly in accepted heterotopic murine cardiac allografts.
METHODS
The rate of development of interstitial fibrosis or TVS development was determined by computerized analysis of tissue sections from DBA/2-->C57BL/6 heterotopic cardiac allografts after immunosuppression with gallium nitrate.
RESULTS
In accepted cardiac allografts, neointimal fibrosis developed by 30 days after transplant, whereas TVS was minimal by day 30, and maximal by day 60. Variable levels of fibrosis were found throughout the allografts. DBA/2-->DBA/2 cardiac isografts never displayed TVS in this time period, but displayed allograft-like fibrosis within 60 days of transplantation.
CONCLUSIONS
Interstitial fibrosis can be dissociated from the TVS development in this experimental model of chronic cardiac allograft rejection. Apparently, it is caused, at least in part, by alloantigen-independent factors other than TVS-related tissue ischemia.
背景
本研究探讨了移植血管硬化（TVS）与组织纤维化之间的关系，这是慢性排斥反应的特征，在已接受的异位小鼠心脏同种异体移植中可能迅速发展。
方法
通过对硝酸镓免疫抑制后DBA/2→C57BL/6异位心脏同种异体移植组织切片进行计算机分析，确定间质纤维化或TVS发展的速率。
结果
在已接受的心脏同种异体移植中，移植后30天出现新内膜纤维化，而TVS在第30天时最小，在第60天时最大。在整个同种异体移植中发现了不同程度的纤维化。DBA/2→DBA/2心脏同基因移植在这段时间内从未出现TVS，但在移植后60天内出现了同种异体移植样纤维化。
结论
在这个慢性心脏同种异体移植排斥反应的实验模型中，间质纤维化与TVS的发展可以分离。显然，它至少部分是由除TVS相关组织缺血之外的同种异体抗原非依赖性因素引起的。
Zotero 插件