Pickeral J J, Marcus R J, Hsia S, Miller L L, Nghiem D D
Department of Laboratory Medicine, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 19212, USA.
Transplantation. 1997 Oct 27;64(8):1202-5. doi: 10.1097/00007890-199710270-00021.
Although previous studies have not demonstrated a clear correlation between interleukin (IL) 2 receptor levels and immunological events after transplantation, many still suggest that these levels have clinical utility. A total of 759 serial measurements of both IL-2R and creatinine were compared over time and correlated with rejection episodes, clinical course, and immunosuppression. The profiles for the 40 patients showed several patterns, including correlation with changes in creatinine levels or with renal dysfunction, peaks in the absence of clinical findings, and discordant IL-2R and creatinine levels. Wide baseline variations in IL-2R levels confounded comparison of mean values and definition of a statistically significant rise. While tending to correlate with immunological events, elevations in IL-2R also occurred in clinically normal patients. IL-2R appears to lack specificity for immunological events. Thus, we conclude that IL-2R measurement does not have clinical diagnostic utility for monitoring renal transplant recipients.
尽管先前的研究尚未证明白细胞介素（IL）2受体水平与移植后的免疫事件之间存在明确的相关性，但许多研究仍表明这些水平具有临床实用性。对759次白细胞介素-2受体（IL-2R）和肌酐的连续测量值随时间进行了比较，并与排斥反应、临床病程和免疫抑制相关联。40例患者的情况呈现出几种模式，包括与肌酐水平变化或肾功能障碍的相关性、在无临床症状时出现峰值，以及IL-2R和肌酐水平不一致。IL-2R水平的广泛基线差异使平均值的比较以及统计学上显著升高的定义变得复杂。虽然IL-2R水平倾向于与免疫事件相关，但在临床正常的患者中也会出现升高。IL-2R似乎缺乏对免疫事件的特异性。因此，我们得出结论，测量IL-2R对监测肾移植受者没有临床诊断价值。
