Moriuchi T
Hokkaido Igaku Zasshi. 1979 Sep;54(5):487-99.
The antigenicity of tumor-associated antigen (TAA) was compared between 3-methylcholanthrene-induced rat fibrosarcoma KMT-17 and Friend murine leukemia virus-infected KMT-17 (FV-KMT-17) cells. The antigenicity was classified into immunosensitivity and immunogenicity, and studied from the viewpoint of humoral immunity. The immunosensitivity to anti TAA antibodies increased by artificial infection of KMT-17 cells with Friend virus. The results suggested that an increase of lateral mobility of TAA on the cell surface contributes to the increase of immunosensitivity. Concerning the immunogenicity of TAA, an augmentation of anti-TAA antibody formation was demonstrated when FV-KMT-17 cells were used as the immunogen. In this case, a physical association between TAA and virus-associated antigen (VAA) was suggested to be very important to increase the immunogenicity of TAA.
对3-甲基胆蒽诱导的大鼠纤维肉瘤KMT-17细胞和感染了Friend鼠白血病病毒的KMT-17细胞（FV-KMT-17）之间肿瘤相关抗原（TAA）的抗原性进行了比较。抗原性分为免疫敏感性和免疫原性，并从体液免疫的角度进行了研究。用Friend病毒人工感染KMT-17细胞后，其对抗TAA抗体的免疫敏感性增加。结果表明，TAA在细胞表面横向移动性的增加有助于免疫敏感性的提高。关于TAA的免疫原性，当使用FV-KMT-17细胞作为免疫原时，抗TAA抗体的形成增加。在这种情况下，TAA与病毒相关抗原（VAA）之间的物理关联对于提高TAA的免疫原性非常重要。
