Subbiah M T, Buascaglia M D
Res Commun Chem Pathol Pharmacol. 1976 Mar;13(3):529-39.
To investigate the mechanism of hypercholesterolemia noted in pregnancy, cholesterol catabolism and excretion was investigated during late pregnancy in the rat. Pregnancy was associated with an increase in plasma cholesterol and a decrease in the concentration of both cholesterol and bile acids in bile (with no difference in bile flows). The appearance of injected 4-C14-cholesterol in the bile of pregnant females was less than that of virgin females with a significant decrease in the bile acid fraction. The cholic/chenodeoxycholic acid ratio of newly formed C14 bile acids in pregnant rat bile was lower than in the bile of virgin female rats. Surprisingly, cholesterol balance studies failed to reveal any difference in the fecal excretion of neutral sterols or bile acids between virgin and pregnant female rats. The hypercholesterolemia of pregnancy could be partially due to the decrease in biliary cholesterol and bile acid excretion. The lack of difference in fecal cholesterol excretion is perhaps due to the operation of compensatory absorption mechanisms in the intestine which needs further investigation.
为研究孕期出现的高胆固醇血症的机制，对大鼠妊娠晚期的胆固醇分解代谢及排泄情况进行了研究。妊娠与血浆胆固醇升高以及胆汁中胆固醇和胆汁酸浓度降低相关（胆汁流量无差异）。妊娠雌性大鼠胆汁中注射的4-C14-胆固醇的出现量少于未孕雌性大鼠，胆汁酸部分显著减少。妊娠大鼠胆汁中新形成的C14胆汁酸的胆酸/鹅去氧胆酸比值低于未孕雌性大鼠的胆汁。令人惊讶的是，胆固醇平衡研究未能揭示未孕和妊娠雌性大鼠中性固醇或胆汁酸的粪便排泄有任何差异。孕期的高胆固醇血症可能部分归因于胆汁中胆固醇和胆汁酸排泄的减少。粪便胆固醇排泄缺乏差异可能是由于肠道中代偿性吸收机制的作用，这需要进一步研究。
