异丙肾上腺素对人及大鼠妊娠子宫肌层摄取钙-45的影响。

Effect of isoproterenol on uptake of calcium-45 by pregnant human and rat myometrium.

作者信息

Hodgson B J

出版信息

Res Commun Chem Pathol Pharmacol. 1976 May;14(1):141-51.

Abstract

Rat and human myometria contract is response to substitution of external Na+ with Li+. This contraction was accompanied by elevation of 45Ca uptake in rat but not human uterus. The lanthanum technique failed to demonstrate elevation of cellular 45Ca in human myometrium by Li+ substitution. It also failed to demonstrate reduction of Li-elevated 45Ca uptake by isoproterenol or drugs considered to inhibit calcium influx, in rat myometrium although these drugs prevented Li-induced contraction. In human myometrium, isoproterenol increased 45Ca uptake. This probably represents increased extracellular calcium binding. Isoproterenol relaxed depolarized human myometrium provided that the external calcium had been removed for 15 minutes.

摘要

大鼠和人类子宫肌层的收缩是对用Li⁺替代细胞外Na⁺的反应。这种收缩伴随着大鼠子宫（而非人类子宫）对⁴⁵Ca摄取的增加。镧技术未能证明Li⁺替代会使人类子宫肌层细胞内的⁴⁵Ca升高。该技术也未能证明异丙肾上腺素或被认为可抑制钙内流的药物能降低Li⁺升高的大鼠子宫肌层对⁴⁵Ca的摄取，尽管这些药物可阻止Li⁺诱导的收缩。在人类子宫肌层中，异丙肾上腺素会增加⁴⁵Ca的摄取。这可能代表细胞外钙结合增加。如果已去除细胞外钙15分钟，异丙肾上腺素可使去极化的人类子宫肌层松弛。