Thompson R H, Todd J R
Res Vet Sci. 1976 May;20(3):257-60.
Although the rise in blood copper is associated with onset of the acute haemolytic crisis of chronic copper poisoning in sheep, the sudden fall in erythrocyte glutathione is apparently not due to a direct action of the copper. Moreover the reduced glutathione of the red cells is converted to some form that is not capable of regeneration by the pentose-phosphate mechanism. Only negligible inhibition of the pentose-phosphate enzymes occurs. As the haemolysis proceeds, there is a rapid recovery of erythrocyte glutathione levels, and a marked increase in pentose-phosphate enzyme activity, consistent with influx of young red cells. It seems that the release of copper into blood from liver at the haemolytic crisis is associated with an increase of the oxidative state of the blood, possibly by simultaneous release of other components from the liver.
虽然血铜升高与绵羊慢性铜中毒急性溶血危机的发作有关，但红细胞谷胱甘肽的突然下降显然不是铜的直接作用所致。此外，红细胞的还原型谷胱甘肽被转化为某种不能通过磷酸戊糖机制再生的形式。磷酸戊糖酶仅受到微不足道的抑制。随着溶血的进行，红细胞谷胱甘肽水平迅速恢复，磷酸戊糖酶活性显著增加，这与年轻红细胞的流入一致。溶血危机时肝脏中铜释放入血似乎与血液氧化状态的增加有关，可能是肝脏同时释放了其他成分。
