Martínez M, Vayá A, Labios M, Gabriel F, Guiral V, Aznar J
Department of Clinical Pathology, Hospital La Fe, Valencia, Spain.
Clin Hemorheol Microcirc. 1997 May-Jun;17(3):193-8.
This study examined ninety-six patients with essential arterial hypertension (WHO grade I-II) who had been under treatment for a period of at least one year before participating in the study. When the study began the patients received no drug treatment for one month. At the end of this washout period their basal situation was evaluated and drug treatment was begun (26 patients on calcium antagonists, 39 on beta-blockers and 31 on angiotensin converting enzyme inhibitors). The patients were evaluated again after one and two years of uninterrupted treatment with the chosen medication. The results obtained indicate that in a basal situation hypertensive patients have higher blood viscosity and erythrocyte rigidity values than the control group. Regardless of the drug treatment used, the patients experienced during the study a progressive deterioration of their hemorheological situation consisting of an increase in red blood cell rigidity and increased blood viscosity. These results indicate the importance of evaluating the hemorheological parameters of hypertensive patients and suggest that it may be advisable to include in their treatment some kind of medication that prevents progressive rheological deterioration.
本研究对96例原发性动脉高血压患者（WHO I-II级）进行了检查，这些患者在参与研究前已接受至少一年的治疗。研究开始时，患者有一个月未接受药物治疗。在这个洗脱期结束时，评估他们的基础状况并开始药物治疗（26例患者使用钙拮抗剂，39例使用β受体阻滞剂，31例使用血管紧张素转换酶抑制剂）。在用所选药物进行一年和两年不间断治疗后，再次对患者进行评估。获得的结果表明，在基础状况下，高血压患者的血液粘度和红细胞刚性值高于对照组。无论使用何种药物治疗，患者在研究期间血液流变学状况都逐渐恶化，表现为红细胞刚性增加和血液粘度升高。这些结果表明评估高血压患者血液流变学参数的重要性，并建议在他们的治疗中可能宜加入某种防止血液流变学状况逐渐恶化的药物。
