脑内血管紧张素在大鼠口渴和钠食欲中的作用。
Role of brain angiotensin in thirst and sodium appetite of rats.
作者信息
Weisinger R S, Blair-West J R, Burns P, Denton D A, Tarjan E
机构信息
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville VIC, Australia. richard_weisinger.hfi;camuwaye.unimelb.edu.au
出版信息
Peptides. 1997;18(7):977-84. doi: 10.1016/s0196-9781(97)00077-6.
The role of brain angiotensin II (ANG II) in water, Na and food intake of rats was studied. Intracerebroventricular (i.c.v.) infusion (100 micrograms/h) of the non-peptide ANG II receptor antagonist losartan (type 1), but not PD123319 (type 2), completely blocked water intake caused by i.c.v. infusion of ANG II at 50 ng/h. Following food deprivation, food intake was reduced by PD123319 and associated water intake was decreased by losartan or PD123319. Neither water intake after water deprivation nor Na intake after Na depletion was altered by losartan or PD123319. In conclusion, evidence was consistent with a role for brain ANG II in both food and water intake after food deprivation but not in thirst subsequent to water deprivation or Na intake after Na depletion alone.
研究了脑内血管紧张素II（ANG II）在大鼠水、钠和食物摄入中的作用。脑室内（i.c.v.）输注非肽类ANG II受体拮抗剂氯沙坦（1型），而非PD123319（2型），以100微克/小时的速度，完全阻断了以50纳克/小时的速度脑室内输注ANG II所引起的水摄入。食物剥夺后，PD123319可减少食物摄入，氯沙坦或PD123319可减少相关的水摄入。氯沙坦或PD123319均未改变水剥夺后的水摄入或钠缺乏后的钠摄入。总之，有证据表明，脑内ANG II在食物剥夺后的食物和水摄入中起作用，但在水剥夺后的口渴或单独的钠缺乏后的钠摄入中不起作用。
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