Owen D B, Morley J S, Ensor D M, Allen Y S, Miles J B
Department of Evolutionary & Environmental Biology, University of Liverpool, UK.
Peptides. 1997;18(7):1015-21. doi: 10.1016/s0196-9781(97)00043-0.
MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and mesenchephalic dopaminergic neurons. The dose-response relationships are biphasic ("bell shaped"), maximal responses being obtained with 10(-6) M concentrations of MPF. MPF and nerve growth factor seem to act on different receptors, because their effects on cholinergic neurons are synergistic.
MPF是一种四肽（结构为赖氨酸-赖氨酸-甘氨酸-谷氨酸），在体内可引发多种神经营养作用，这与它在神经元再生中的作用相符。为支持这一作用，我们现在表明，MPF可刺激培养的星形胶质细胞增殖以及新皮质胆碱能神经元和中脑多巴胺能神经元培养物中的神经突生长。剂量反应关系呈双相性（“钟形”），在MPF浓度为10(-6) M时获得最大反应。MPF和神经生长因子似乎作用于不同的受体，因为它们对胆碱能神经元的作用是协同的。
