Shet T, Desai S, Prabhu S, Amarapurkar D
Department of Pathology, T N Medical College, Mumbai.
Indian J Gastroenterol. 1997 Oct;16(4):140-1.
To study mucin histochemistry of the normal esophagus, esophageal adenocarcinoma, and carcinoma exhibiting glandular and squamous elements, to ascertain the origin of these tumors.
Mucin histochemistry was studied in sections of the normal cardioesophageal junction obtained from 25 post-mortem specimens and in 12 mucin-secreting esophageal carcinomas.
The normal submucosal esophageal glands and three adenocarcinomas secreted predominantly sulfomucins; a mixture of neutral and sialomucins was seen in the nine carcinomas with squamous and glandular traits. Barrett's metaplasia was not encountered.
In the absence of Barrett's metaplasia, esophageal adenocarcinoma probably arises from the submucosal glands, whereas squamous carcinomas with mucin-secreting component could arise from metaplastic change in squamous epithelium, cardiac glands, or multipotent stem cells in the epithelium.
研究正常食管、食管腺癌以及兼具腺性和鳞状成分的癌的黏蛋白组织化学，以确定这些肿瘤的起源。
对取自25份尸检标本的正常贲门食管交界处切片以及12例分泌黏蛋白的食管癌进行黏蛋白组织化学研究。
正常食管黏膜下腺和3例腺癌主要分泌硫黏蛋白；在9例具有鳞状和腺性特征的癌中可见中性黏蛋白和涎黏蛋白的混合物。未发现巴雷特化生。
在无巴雷特化生的情况下，食管腺癌可能起源于黏膜下腺，而具有分泌黏蛋白成分的鳞状癌可能起源于鳞状上皮、贲门腺或上皮中的多能干细胞的化生改变。
