Strohmaier W L, Hoelz K J, Bichler K H
Department of Urology, Eberhard Karls University, Tübingen, Germany.
Eur Urol. 1997;32(3):294-300.
This prospective study was initiated to assess the significance of spot urine specimens (SU) for the metabolic evaluation of stone formers.
68 stone patients (51 males, 17 females) and 20 controls (9 males, 11 females) participated. On 3 consecutive days, urine was collected. Fasting (SU1) and postprandial (SU2) SU were obtained. From these, aliquots were taken, all the other urine was mixed to obtain 24-hour timed specimens (24hU). In all specimens, pH, specific gravity, creatinine, calcium, magnesium, phosphate, citrate, uric and oxalic acids were measured. The latter analytes were related to creatinine (mmol/g creatinine). Pearson correlation coefficients with their levels of significance and the day-to-day variation were calculated. Using the values in the control group, normal values (means +/- 2 SD) were established.
There was a significant correlation (p < 0.0001) between SU and 24hU for all parameters examined. The day-to-day variation of all analytes was considerable in SU and 24hU.
Despite a minor inaccuracy by relating parameters to creatinine, SU are sufficient in the routine metabolic evaluation of stone formers, since a third of all 24hU has to be rejected because of considerable collection errors. SU circumvent this problem. Because of the day-to-day variation, 3 SU should be obtained to overcome the doubtful significance of one single specimen.
开展这项前瞻性研究以评估随机尿标本（SU）对结石形成者代谢评估的意义。
68例结石患者（51例男性，17例女性）和20例对照者（9例男性，11例女性）参与研究。连续3天收集尿液。获取空腹（SU1）和餐后（SU2）随机尿标本。从中取出等分试样，将所有其他尿液混合以获得24小时定时标本（24hU）。在所有标本中，测量pH值、比重、肌酐、钙、镁、磷酸盐、柠檬酸盐、尿酸和草酸。后几种分析物与肌酐相关（mmol/g肌酐）。计算皮尔逊相关系数及其显著性水平和每日变化。利用对照组的值确定正常值（均值±2标准差）。
在所检测的所有参数方面，随机尿标本与24小时定时标本之间存在显著相关性（p<0.0001）。随机尿标本和24小时定时标本中所有分析物的每日变化都相当大。
尽管将参数与肌酐相关联存在轻微不准确之处，但随机尿标本在结石形成者的常规代谢评估中足够用，因为由于相当多的收集误差，所有24小时定时标本中有三分之一不得不被舍弃。随机尿标本避免了这个问题。由于每日变化，应获取3份随机尿标本以克服单个标本意义存疑的问题。
