硬尾醇内酯的微生物转化

Microbial transformation of sclareolide.

作者信息

Farooq A, Choudhary M I

机构信息

H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.

出版信息

J Nat Prod. 1997 Oct;60(10):1038-40. doi: 10.1021/np970076h.

DOI:10.1021/np970076h

PMID:9358647

Abstract

The microbial transformation of sclareolide (1) by Curvularia lunata afforded five oxidized metabolites identified as 3-ketosclareolide (2), 1 beta-hydroxysclareolide (3), 3 beta-hydroxysclareolide (4), 1 alpha,3 beta-dihydroxysclareolide (5), and 1 beta, 3 beta-dihydroxysclareolide (6). Fermentations of 1 with Aspergillus niger also produced metabolites 2-6. Metabolites 2-5 were obtained by fermention with Gibberella fujikuroii, while fermentation with Fusarium lini afforded metabolites 4 and 5.

摘要

新月弯孢霉对香紫苏内酯（1）的微生物转化产生了5种氧化代谢产物，分别鉴定为3-酮香紫苏内酯（2）、1β-羟基香紫苏内酯（3）、3β-羟基香紫苏内酯（4）、1α,3β-二羟基香紫苏内酯（5）和1β,3β-二羟基香紫苏内酯（6）。黑曲霉对1的发酵也产生了代谢产物2-6。代谢产物2-5是通过藤仓赤霉发酵得到的，而亚麻镰刀菌发酵则产生了代谢产物4和5。