遗传性甲状腺髓样癌和嗜铬细胞瘤的克隆起源
Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma.
作者信息
Baylin S B, Gann D S, Hsu S H
出版信息
Science. 1976 Jul 23;193(4250):321-3. doi: 10.1126/science.935869.
PMID:935869
Abstract
A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.
摘要
一名患有遗传性甲状腺髓样癌和嗜铬细胞瘤的黑人女性在正常组织（血液、甲状腺和肾上腺）中是葡萄糖-6-磷酸脱氢酶A和B型的嵌合体；甲状腺髓样癌和嗜铬细胞瘤组织均仅显示B型。这一发现提示每个肿瘤都起源于单一克隆。在人类中进行类似研究的其他遗传性肿瘤似乎起源于多克隆。
Zotero 插件