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遗传性甲状腺髓样癌和嗜铬细胞瘤的克隆起源

Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma.

作者信息

Baylin S B, Gann D S, Hsu S H

出版信息

Science. 1976 Jul 23;193(4250):321-3. doi: 10.1126/science.935869.

DOI:10.1126/science.935869
PMID:935869
Abstract

A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

摘要

一名患有遗传性甲状腺髓样癌和嗜铬细胞瘤的黑人女性在正常组织（血液、甲状腺和肾上腺）中是葡萄糖-6-磷酸脱氢酶A和B型的嵌合体；甲状腺髓样癌和嗜铬细胞瘤组织均仅显示B型。这一发现提示每个肿瘤都起源于单一克隆。在人类中进行类似研究的其他遗传性肿瘤似乎起源于多克隆。

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Clonality Studies in the Analysis of Adrenal Medullary Proliferations: Application Principles and Limitations.肾上腺髓质增生分析中的克隆性研究：应用原则与局限性
Endocr Pathol. 1998 Winter;9(1):301-316. doi: 10.1007/BF02739690.
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Clonality of Endocrine Proliferative Lesions: A Critical Reappraisal.内分泌增生性病变的克隆性：一项批判性重新评估。
Endocr Pathol. 1998 Winter;9(1):281-285. doi: 10.1007/BF02739687.
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The clonal origin and clonal evolution of epithelial tumours.上皮性肿瘤的克隆起源与克隆进化
Int J Exp Pathol. 2000 Apr;81(2):89-116. doi: 10.1046/j.1365-2613.2000.00142.x.
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Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression.Trk家族神经营养因子受体在甲状腺髓样癌发生发展中的作用
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4540-5. doi: 10.1073/pnas.96.8.4540.
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Deletion mapping of chromosome 1p and 22q in pheochromocytoma.嗜铬细胞瘤中1号染色体短臂和22号染色体长臂的缺失图谱分析
Jpn J Cancer Res. 1993 Apr;84(4):402-8. doi: 10.1111/j.1349-7006.1993.tb00150.x.
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Clin Investig. 1993 Jun;71(6):488-502. doi: 10.1007/BF00180066.
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Familial endocrine tumors.家族性内分泌肿瘤
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