Schilling R F
Semin Hematol. 1976 Jul;13(3):169-76.
Sixty-one persons splenectomized for hereditary spherocytosis have been studied and compared to 36 nonsplenectomized clinically affected and to 77 nonaffected family members. Serum IgM levels were reduced by 25% and IgD levels were nearly doubled in the splenectomized group. No fatal bacterial infection was identified by history covering a total of 800 postsplenectomy years. Platelet counts remained elevated for many years after removal of the spleen, as did the number of leukocytes, lymphocytes, and monocytes. Heinz bodies were seen in 3% of red cells after splenectomy. Though within the range of "normal," reticulocyte levels and serum bilirubin levels were satistically higher in the splenectomized group than in the nonaffected persons. Hemoglobin levels were higher in splenectomized affected persons than in matched controls of the same sex and maturity.
对61例因遗传性球形红细胞增多症而行脾切除术的患者进行了研究，并与36例有临床症状但未行脾切除术的患者以及77例未受影响的家庭成员进行了比较。脾切除组的血清IgM水平降低了25%，IgD水平几乎翻倍。在涵盖总共800个脾切除术后年份的病史中，未发现致命的细菌感染。脾切除后，血小板计数多年来一直升高，白细胞、淋巴细胞和单核细胞的数量也是如此。脾切除术后，3%的红细胞中可见海因茨小体。尽管在“正常”范围内，但脾切除组的网织红细胞水平和血清胆红素水平在统计学上高于未受影响的人群。脾切除术后受影响的患者血红蛋白水平高于相同性别和成熟度的匹配对照组。
